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502120 Akute Leukämien (V) (WiSe 2024/2025)
Short comment
- Allgemeine Pathologie
Contents, comment
-
Diese Veranstaltung ist Teil des Clusters "onkologische Erkrankungen des Blutes", den Link zum Lernraum finden Sie hier: https://moodle.uni-bielefeld.de/course/view.php?id=5831
Studierende 1-72
Die Studierenden können"�pathologische Veränderungen der Blutzellen im Mikroskop erkennen und ihre Charakteristika erklären.Die Studierenden können"�pathologische Veränderungen der Blutzusammensetzung und deren Entstehung erklären.
Die Studierenden können"�typische klinische Präsentationen akuter myeloischer und lymphatischer Leukämien erläutern.
Die Studierenden kennen die Techniken der mikroskopischen Untersuchung von Blut und Knochenmark, Immunphänotypisierung und molekularen Techniken (Zytogenetik, FISH, Sequenzierungen)
Akute LeukämienDefinition: Klonale (neoplastische) Expansion unreifer Blasten auf >20% (30%*) im Knochenmark oder im peripheren Blut
FAB-Klassifikation*: Morphologie, Histochemie
?"�"�"�"�"�"�"�Akute myeloische Leukämien: AML M0-M7
?"�"�"�"�"�"�"�Akute lymphatische Leukämien: L1, L2, L3
?"�"�"�"�"�"�"�Akute undifferenzierte Leukämien
Epidemilologie
Klinische Leitsymptome
Akute Myeloische Leukämien:
Diagnostik:
?"�"�"�"�"�"�"�Mikroskopische Untersuchung des Blutes: Differentialblutbild, Blastenausschwemmung
?"�"�"�"�"�"�"�Knochenmark: Linksverschiebung, Hiatus leucaemicus
?"�"�"�"�"�"�"�Prinzipien der Immunphänotypisierung
?"�"�"�"�"�"�"�Molekulare Diagnostik:
o"�"�Zytogenetik
o"�"�FISH
o"�"�Sequenzierungstechniken
WHO-Klassifikation: Berücksichtigung molekularer Befunde
Risikostratifikation anhand Molekularer Befunde
Grundzüge der Therapie: Onkopedia!
Akute Lymphatische Leukämien
Diagnostik:
?"�"�"�"�"�"�"�Mikroskopische Untersuchung des Blutes: Differentialblutbild, Blastenausschwemmung
?"�"�"�"�"�"�"�Knochenmarksunterscuhung: Immunhistologie
?"�"�"�"�"�"�"�Subtypisierung: Immunphänotypisierung. MRD-Diagnostik
WHO-Klassifikation
Grundzüge der Therapie: Onkopedia!
Bibliography
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Höfler, Kreipe, Moch: Pathologie - Das Lehrbuch ; Fuchs, Staib, Brümmendorf: Manual Hämatologie
Teaching staff
Managed course
Dates ( Calendar view )
| Frequency | Weekday | Time | Format / Place | Period | |
|---|---|---|---|---|---|
| one-time | Mo | 08:15-09:00 | ONLINE findet Online statt | 06.01.2025 |
Subject assignments
| Module | Course | Requirements | |
|---|---|---|---|
| 5-I-BI-T Blut und Immunsystem I | Blut- und Immunsystem I (Vorlesung) | Student information |
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