Personen- und Einrichtungssuche

Herr Prof. Dr. Thomas Huser

Bild der Person Herr Prof. Dr. Thomas Huser - Öffnet das Bild in voller Größe auf einer neuen Seite


Curriculum Vitae

Thomas R. Huser, Ph.D.
University of Bielefeld, Bielefeld, Germany
Department of Physics, D3, Universitätsstr. 25, 33615 Bielefeld, Germany

Professional Preparation:
University of Basel, Switzerland Physics M.A. 1992
University of Basel, Switzerland Physics M.S. 1994
University of Basel, Switzerland Physics Ph.D. 1998
Lawrence Livermore National Laboratory, Livermore, CA Materials Science Postdoc 1998-2000

Positions and Employment :
2000–2002 Staff Physicist, Lawrence Livermore National Laboratory (LLNL), Livermore, CA
2002–2005 Scientific Capability Leader “Nanophotonics,” Chemical Biology and Nuclear Science Division, LLNL
2003–2005 Group Leader “Biophotonics,” Medical Physics and Biophysics Division, LLNL
2004–2005 Deputy Director, Physical Biosciences Institute, LLNL
2005–2011 Chief Scientist, Center for Biophotonics Science and Technology, UC Davis
2005–2011 Associate Professor, Department of Internal Medicine, UC Davis
2006–2011 Co-Director, Translational Working Group, Clinical Translational Science Center, UC Davis
2008–2011 Co-Chair, Designated Emphasis in Biophotonics, University of California, Davis
2011- Professor, Department of Physics, University of Bielefeld, Germany
2011- Adjunct Professor, Department of Internal Medicine, University of California, Davis, USA

Professional Societies and Public Advisory Committees:
2005, 2007 ad hoc Member, Special Emphasis Panel “Nanoscience and Nanotechnology”, NIH
2009 ad hoc Member, Physical Sciences Oncology Centers, NCI-NIH
2008 ad hoc Member, “Career” grants, National Science Foundation
2009 ad hoc Member, BISH Panel, National Science Foundation
1994– German Physical Society

1998 graduated “summa cum laude”, University of Basel, Switzerland
2002 Norbert J. Kreidl Award of the Glass and Optical Division of the American Ceramic Society
2004 Excellence in Publication Award of the Associate Director, Chemistry and Materials Science, LLNL
2006 “Above and Beyond” Award for undergraduate teaching, Center for Biophotonics
2008-2011 Visiting Professor, University of Tromso, Norway
2009 Guest Editor for Journal of Biophotonics on “Biophotonics in Regenerative Medicine”
2012-2015 Member of the Editorial Advisory Board, “Applied Spectroscopy”
2015/2017 Chair, Subcommittee “Biophotonics”, CLEO Europe – largest Europ.Photonics conf.
2017 - Member of the Editorial Board, "Scientific Reports"
2019- Associate Editor, "BME Frontiers", Science Partner Journals

Most recent Publications:
2022 L. Wang, A. Sandmeyer, W. Hübner, H. Li, T. Huser, and B.K. Chen, A Replication-Competent HIV Clone Carrying GFP-Env Reveals Rapid Env Recycling at the HIV-1 T Cell Virological Synapse, Viruses 14(1), 38 (2022)

2021 H. Füser, C. Pilger, C. Kong, T. Huser and W. Traunspurger, Polystyrene microbeads influence lipid storage distribution in C. elegans as revealed by coherent anti-Stokes Raman scattering (CARS) microscopy, Environ. Pollut. 294, 118662 (2021)

2021 M. Lachetta, G. Wiebusch, W. Hübner, J. Schulte am Esch, T. Huser, and M. Müller, Dual color DMD-SIM by temperature controlled laser wavelength matching, Opt. Express 29(24), 39696-39708 (2021)

2021 M.I. Barria, R.A. Alvarez, K. Law, D. Wolfson, T. Huser, and B.K. Chen, Endocytic Motif on a Biotin-Tagged HIV-1 Env Modulates the Co-Transfer of Env and Gag during Cell-to-Cell Transmission, Viruses 13(9), 1729 (2021)

2021 A.K. Engdahl, S. Belle, T.-C. Wang, R. Hellmann, T. Huser, M. Schüttpelz, Large field-of-view super-resolution optical microscopy based on planar polymer waveguides, ACS Photonics 8(7), 1944-1950 (2021)

2021 A. Sandmeyer, M. Lachetta, H. Sandmeyer, W. Hübner, T. Huser, and M. Müller, Cost-effective live cell structured illumination microscopy with video-rate imaging, ACS Photonics 8(6), 1639-1648 (2021)

2021 C. Pilger, J. Pospíšil, M. Müller, M. Ruoff, M. Schütte, H. Spiecker, and T. Huser, Super-resolution fluorescence microscopy by line-scanning with an unmodified two-photon microscope microscopy, Phil. Trans. R. Soc. A. 379, 20200300 (2021),

2021 J. Pospisil, G. Wiebusch, K. Fliegel, M. Klima, and T. Huser, Highly compact and cost-effective 2-beam super-resolution structured illumination microscope based on all-fiber optic components, Opt. Express 29(8), 11833-11844 (2021)

2021 Z.H. Shah, M. Müller, T.-C. Wang, P.M. Scheidig, A. Schneider, M. Schüttpelz, T. Huser, and W. Schenck, Deep-learning based denoising and reconstruction of super-resolution structured illumination microscopy images, Photonics Res. 9(5), B168-B180 (2021)

2021 B. Kaltschmidt, A.D.E. Fitzek, J. Schaedler, C. Förster, C. Kaltschmidt, T. Hansen, F. Steinfurth, B.A. Windmöller, C. Pilger, C. Kong, K. Singh, A. Nierhaus, D. Wichmann, J. Sperhake, K. Püschel, T. Huser, M. Krüger, S.C. Robson, L. Wilkens, and J. Schulte am Esch, Hepatic vasculopathy and regenerative responses of the liver in fatal cases of COVID-19, Clin. Gastroenterol. Hepatol. 19, 1726-1729 (2021),

2021 C. Kong, S. Bobe, C. Pilger, M. Lachetta, C.I. Øie, N. Kirschnick, V. Mönkemöller, W. Hübner, C. Förster, M. Schüttpelz, F. Kiefer, T. Huser, and J. Schulte am Esch, Multiscale and multimodal optical imaging of the ultrastructure of human liver biopsies, Front. Physiol. 12, 637136 (2021),

2021 M. Lachetta, H. Sandmeyer, A. Sandmeyer, J. Schulte am Esch, T. Huser, and M. Müller, Simulating digital micromirror devices for patterning coherent excitation light in structured illumination microscopy, Phil. Trans. R. Soc. A. 379, 20200147 (2021),

2021 F. Dell’Olio, J. Su, T. Huser, V. Sottile, L. E. Cortés-Hernández, and C. Alix-Panabières, Photonic Technologies for Liquid Biopsies: Recent Advances and Open Research Challenges, Laser Photonics Rev. 15(1), 2000255 (2021). 202000255

2020 O. Wrede, S. Bergmann, Y. Hannappel, T. Hellweg and T. Huser, Smart microgels investigated by super-resolution fluorescence microscopy: influence of the monomer structure on the particle morphology, Soft Matter 16(34), 8078-8084 (2020),

2020 L. Reymond, T. Huser, V. Ruprecht, and S. Wieser, Modulation-enhanced localization microscopy, J. Phys. Photonics 2(4), 041001 (2020)

2020 T. Stephan, C. Bruser, M. Deckers, A.M. Steyer, F. Balzarotti, M. Barbot, T.S. Behr, G. Heim, W. Hübner, P. Ilgen, F. Lange, D. Pacheu-Grau, J.K. Pape, S. Stoldt, T. Huser, S.W. Hell, W. Möbius, P. Rehling, D. Riedel, and S. Jakobs, MICOS assembly controls mitochondrial inner membrane remodeling and crista junction redistribution to mediate cristae formation, EMBO J., e10405(2020)

2020 C. Kong, C. Pilger, H. Hachmeister, X. Wei, T.H. Cheung, C.S.W. Lai, N.P. Lee, K.K. Tsia, K.K.Y. Wong, and T. Huser, High-contrast, fast chemical imaging by coherent Raman scattering using a self-synchronized two-colour fibre laser, Light Sci Appl 9, 25 (2020).

2020 P. Otto, S. Bergmann, A. Sandmeyer, M. Dirksen, O. Wrede, T. Hellweg, and T. Huser, Resolving the internal morphology of core–shell microgels with super-resolution fluorescence microscopy, Nanoscale Adv. 2, 323 (2020)

2020 A. Descloux, M. Müller, V. Navikas, A. Markwirth,
R. van den Eynde, T. Lukes, W. Hübner, T. Lasser, A. Radenovic, P. Dedecker, and T. Huser, High-speed multiplane structured illumination microscopy of living cells using an image-splitting prism, Nanophoton. 9(1), 143-148 (2020)

2019 A. Markwirth, M. Lachetta, V. Mönkemöller, W. Hübner, R. Heintzmann, T. Huser, and M. Müller, Video-rate multi-color structured illumination microscopy with simultaneous real-time reconstruction, Nature Commun. 10(1), 4315 (2019)

Aktuelle Forschungsthemen

Research in my group centers prominently around ultra-sensitive optical microscopy and spectroscopy. Research projects scale from fundamental molecular and biomolecular systems to individual cells and organisms. Specifically, projects include the nondestructive characterization of individual stem cells, cancer cells, and virus-infected cells. A major component is devoted to the development and application of novel super-resolution optical microscopy techniques to dissect virological synapses between cells and to determine the structure and dynamics of tunneling nanotubes between cells. My group also develops nanosensors and novel markers for the long-term cellular and molecular imaging of chemicals, small molecules, and macromolecules in individual cells; Raman and and advanced forms of nonlinear label-free imaging (coherent anti-Stokes Raman spectroscopy (CARS) , doubly-resonant four-wave mixing (DR-FWM)) of individual cells, organelles, and lipoproteins, the study of DNA-protein, protein-protein, and protein-lipid interactions by single molecule fluorescence spectroscopy, and advanced live cell imaging techniques.

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