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Herr Prof. Dr. Thomas Huser

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Curriculum Vitae

Thomas R. Huser, Ph.D.
University of Bielefeld, Bielefeld, Germany
Department of Physics, D3, Universitätsstr. 25, 33615 Bielefeld, Germany
Email: thomas.huser@physik.uni-bielefeld.de

Professional Preparation:
University of Basel, Switzerland Physics M.A. 1992
University of Basel, Switzerland Physics M.S. 1994
University of Basel, Switzerland Physics Ph.D. 1998
Lawrence Livermore National Laboratory, Livermore, CA Materials Science Postdoc 1998-2000

Positions and Employment :
2000–2002 Staff Physicist, Lawrence Livermore National Laboratory (LLNL), Livermore, CA
2002–2005 Scientific Capability Leader “Nanophotonics,” Chemical Biology and Nuclear Science Division, LLNL
2003–2005 Group Leader “Biophotonics,” Medical Physics and Biophysics Division, LLNL
2004–2005 Deputy Director, Physical Biosciences Institute, LLNL
2005–2011 Chief Scientist, Center for Biophotonics Science and Technology, UC Davis
2005–2011 Associate Professor, Department of Internal Medicine, UC Davis
2006–2011 Co-Director, Translational Working Group, Clinical Translational Science Center, UC Davis
2008–2011 Co-Chair, Designated Emphasis in Biophotonics, University of California, Davis
2011- Professor, Department of Physics, University of Bielefeld, Germany
2011- Adjunct Professor, Department of Internal Medicine, University of California, Davis, USA

Professional Societies and Public Advisory Committees:
2005, 2007 ad hoc Member, Special Emphasis Panel “Nanoscience and Nanotechnology”, NIH
2009 ad hoc Member, Physical Sciences Oncology Centers, NCI-NIH
2008 ad hoc Member, “Career” grants, National Science Foundation
2009 ad hoc Member, BISH Panel, National Science Foundation
1994– German Physical Society
1998– American Physical Society

Honors:
1998 graduated “summa cum laude”, University of Basel, Switzerland
2002 Norbert J. Kreidl Award of the Glass and Optical Division of the American Ceramic Society
2004 Excellence in Publication Award of the Associate Director, Chemistry and Materials Science, LLNL
2006 “Above and Beyond” Award for undergraduate teaching, Center for Biophotonics
2008-2011 Visiting Professor, University of Tromso, Norway
2009 Guest Editor for Journal of Biophotonics on “Biophotonics in Regenerative Medicine”
2012-2015 Member of the Editorial Advisory Board, “Applied Spectroscopy”
2015/2017 Chair, Subcommittee “Biophotonics”, CLEO Europe – largest Europ.Photonics conf.
2017 - Member of the Editorial Board, "Scientific Reports"
2019- Associate Editor, "BME Frontiers", Science Partner Journals

Most recent Publications:
2020 P. Otto, S. Bergmann, A. Sandmeyer, M. Dirksen, O. Wrede, T. Hellweg, and T. Huser, Resolving the internal morphology of core–shell microgels with super-resolution fluorescence microscopy, Nanoscale Adv. 2, 323 (2020)

2020 A. Descloux, M. Müller, V. Navikas, A. Markwirth,
R. van den Eynde, T. Lukes, W. Hübner, T. Lasser, A. Radenovic, P. Dedecker, and T. Huser, High-speed multiplane structured illumination microscopy of living cells using an image-splitting prism, Nanophoton. 9(1), 143-148 (2020)

2019 A. Markwirth, M- Lachetta, V. Mönkemöller, W. Hübner, R. Heintzmann, T. Huser, and M. Müller, Video-rate multi-color structured illumination microscopy with simultaneous real-time reconstruction, Nature Commun. 10(1), 4315 (2019)

2019 L. Reymond, J. Ziegler, C. Knapp, T.C. Wang, T. Huser, V. Ruprecht, and S. Wieser, SIMPLE: Structured illumination based point localization estimator with enhanced precision, Opt. Express 27(17), 24578-24590 (2019)

2019 R. Van den Eynde, A. Sandmeyer, W. Vandenberg, Sam Duwé, W. Hübner, T. Huser, P. Dedecker, and M. Müller, Quantitative comparison of camera technologies for cost-effective super- resolution optical fluctuation imaging (SOFI), J. Phys. Photonics 1, 044001 (2019)

2019 H. Mao, R. Diekmann, H.P.H. Liang, V.C. Cogger, D.G. LeCouteur, G.P. Lockwood, N.J. Hunt, M. Schüttpelz, T.R. Huser, V.M. Chen, and P.A.G. McCourt, Cost-efficient nanoscopy reveals nanoscale architecture of liver cells and platelets, Nanophoton. 8(7), 1299-1313 (2019)

2019 T.C. Wang, F. Cochet, F.A. Facchini, L. Zaffaroni, C. Serba, S. Pascal, C. Andraud, A. Sala, F. Di Lorenzo, O. Maury, T. Huser, and F. Peri, Synthesis of the New Cyanine-Labeled Bacterial 
Lipooligosaccharides for Intracellular Imaging and in Vitro Microscopy Studies , Bioconj. Chem. 30(6), 1649-1657 (2019)

2019 M. Simonis, A. Sandmeyer, J. Greiner, B. Kaltschmidt, T. Huser, and S. Hennig, MoNa - A Cost-Efficient, Portable System for the Nanoinjection of Living Cells, Sci. Rep. 9, 5480 (2019)

2019 L. Schermelleh, A. Ferrand, T. Huser, C. Eggeling, M. Sauer, O. Biehlmaier, and G. Drummen, Super-resolution microscopy demystified, Nat. Cell Biol. 21(1), 72-84 (2019)

2019 B. Vukosavljevic, M. Hittinger, H. Hachmeister, C. Pilger, X. Murgia, M. M. Gepp, L. Gentile, H. Huwer, N. Schneider-Daum, T. Huser, C.-M. Lehr, and M. Windbergs, Vibrational spectroscopic imaging and live cell video microscopy for studying differentiation of primary human alveolar epithelial cells, J. Biophoton. 12(6), e201800052 (2019)

2018 C. Pilger, H. Hachmeister, P. Greife, A. Weiß, G. Wiebusch, and T. Huser, Pulse length variation causing spectral distortions in OPO-based hyperspectral coherent Raman scattering microscopy, Opt. Express 26(22), 28312-28322 (2018)

2018 V. Mönkemöller, H. Mao, W. Hübner, G. Dumitriu, P. Heimann, G. Levy, T. Huser, B. Kaltschmidt, C. Kaltschmidt, and C. Øie, Primary rat LSECs preserve their characteristic phenotype after cryopreservation, Sci. Rep. 8, 14657 (2018)

2018 H. Fueser, N. Majdi, A. Haegerbaeumer, C. Pilger, H. Hachmeister, P. Greife, T. Huser, and W. Traunspurger, Analyzing life-history traits and lipid storage using CARS microscopy for assessing effects of copper on the fitness of Caenorhabditis elegans, Ecotoxicol. Environ. Saf. 156, 255–262 (2018)

2018 X. Zhang, M. Mainka, F. Paneff, H. Hachmeister, A. Beyer, A. Gölzhäuser, and T. Huser, Surface-Enhanced Raman Spectroscopy of Carbon Nanomembranes from Aromatic Self-Assembled Monolayers, Langmuir 34(8), 2692-2698 (2018)

2018 S. Bergmann, O. Wrede, T. Huser, and T. Hellweg, Super-resolution optical microscopy resolves network morphology of smart colloidal microgels, Phys. Chem. Chem. Phys. 20(7), 5074-5083 (2018)

2018 C. Øie, V. Mönkemöller, W. Hübner, M. Schüttpelz, B.S. Ahluwalia, T.R. Huser, and P. McCourt, New ways of looking at very small holes – using optical nanoscopy to visualize liver sinusoidal endothelial cell fenestrations, Nanophoton. 7, 575-596 (2018)

2017 R. Heintzmann and T. Huser, Super-resolution structured illumination microscopy, Chem. Rev. 117(23), 13890-13908 (2017)

2017 R. Diekmann, K. Till, M. Müller, M. Simonis, M. Schüttpelz, and T. Huser, Characterization of an industry-grade CMOS camera well suited for single molecule localization microscopy – high performance super-resolution at low cost, Sci. Rep. 7, 14425 (2017)

2017 C. Kong, C. Pilger, H. Hachmeister, X. Wei, T.H. Cheung, C.S.W. Lai, T. Huser, K.K. Tsia, and K.K.Y. Wong, Compact high-power fs ytterbium fiber laser at 1010 nm for biomedical applications, Biomed. Opt. Express 8(11), 4921-4932 (2017)

2017 C. Slotta, T. Schlüter, L.M. Ruiz-Perera, H.M. Kadhim, T. Tertel, E. Henkel, W. Hübner, J.F. Greiner, T. Huser, B. Kaltschmidt, and C. Kaltschmidt, CRISPR/Cas9-mediated knockout of c-REL in HeLa cells results in profound defects of the cell cycle, PLoS One 12(8), e0182373 (2017)

2017 J.P. Schwarzhans, T. Luttermann, D. Wibberg, A. Winkler, W. Hübner, T. Huser, J. Kalinowski, and K. Friehs, A Mitochondrial Autonomously Replicating Sequence from Pichia pastoris for Uniform High Level Recombinant Protein Production, Front. Microbiol. 11, 322-328 (2017)

2017 R. Diekmann, O.I. Helle, Cristina I. Øie, P. McCourt, T.R. Huser, M. Schüttpelz, and B.S. Ahluwalia, Chip-based wide field-of-view nanoscopy, Nature Photon. 11, 322-328 (2017)

2017 D. Jaeger, W. Hübner, T. Huser, J. Mussgnug, and O. Kruse, Nuclear transformation and functional gene expression in the oleaginous microalga Monoraphidium neglectum, J. Biotechnol. 249, 10-15 (2017)

2017 M. Simonis, A. Wilking, W. Hübner, T. Huser, and S. Hennig, Survival rate of eukaryotic cells following electrophoretic nanoinjection, Sci. Rep. 7, 41277 (2017)

2017 S. Bergmann, V. Mönkemöller, and T. Huser, Comment on „Magnetic-field-enabled resolution enhancement in super-resolution imaging“ by M.Zhang et al., Physical Chemistry Chemical Physics 17.10 (2015): 6722-6727, Phys. Chem. Chem. Phys. 19, 4887-4890 (2017)

2016 R. Diekmann, D.L. Wolfson, C. Spahn, M. Heilemann, M. Schüttpelz, and T. Huser, Nanoscopy of bacterial cells immobilized by holographic optical tweezers, Nature Commun. 7, 13711 (2016), DOI: 10.1038/ncomms13711

Aktuelle Forschungsthemen

Research in my group centers prominently around ultra-sensitive optical microscopy and spectroscopy. Research projects scale from fundamental molecular and biomolecular systems to individual cells and organisms. Specifically, projects include the nondestructive characterization of individual stem cells, cancer cells, and virus-infected cells. A major component is devoted to the development and application of novel super-resolution optical microscopy techniques to dissect virological synapses between cells and to determine the structure and dynamics of tunneling nanotubes between cells. My group also develops nanosensors and novel markers for the long-term cellular and molecular imaging of chemicals, small molecules, and macromolecules in individual cells; Raman and and advanced forms of nonlinear label-free imaging (coherent anti-Stokes Raman spectroscopy (CARS) , doubly-resonant four-wave mixing (DR-FWM)) of individual cells, organelles, and lipoproteins, the study of DNA-protein, protein-protein, and protein-lipid interactions by single molecule fluorescence spectroscopy, and advanced live cell imaging techniques.

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