391016 Zellkulturtechnik (BPr) (WiSe 2019/2020)
Contents, comment
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Dieses Modul vermittelt praktische Kenntnisse, die zur Benutzung von Säugerzellkulturen zur Produktion von pharmakologisch bedeutsamen Wirkstoffen notwendig sind. Gegenstand des Praktikums ist die Planung, Modellierung, Optimierung und experimentellen Durchführung einer FedBatch-Kultivierung rekombinanter tierischer Zellen in Rührkesselbioreaktoren zur Produktion eines Glykoproteins. In der Auswertung sollen u.a. die Unterschiede zwischen dem vom Modell vorhergesagten und dem realen Prozessverhalten erarbeitet werden.
Ausgangspunkt der Modellierung und Optimierung des FedBatch-Prozesses sind reale Fermentationsdaten der im Praktikum verwendeten Zelllinie. Dabei kommt das Simulationsprogramm 'Berkeley Madonna' zum Einsatz.In einem weiteren Experiment lernen die Teilnehmerinnen und Teilnehmer den inclined-settler als Zellrückhaltemethode für kontinuierliche Perfusionskulturen kennen und erarbeiten den Einfluss der wichtigsten Betriebsparameter.
Teaching staff
- Herr Prof. Dr. Thomas Noll
- Herr Dr. Oliver Hertel
- und Mitarbeiter
Dates ( Calendar view )
| Frequency | Weekday | Time | Format / Place | Period |
|---|
Subject assignments
| Module | Course | Requirements | |
|---|---|---|---|
| 39-M-MBT11P Spezialisierung Zellkulturtechnik Praktikum | Praktikum Zellkulturtechnik | Ungraded examination
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Student information |
The binding module descriptions contain further information, including specifications on the "types of assignments" students need to complete. In cases where a module description mentions more than one kind of assignment, the respective member of the teaching staff will decide which task(s) they assign the students.
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- Registered number: 9
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- WS2019_391016@ekvv.uni-bielefeld.de
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- Last update basic details/teaching staff:
- Wednesday, November 23, 2022
- Last update times:
- Thursday, November 7, 2019
- Last update rooms:
- Thursday, November 7, 2019
- Type(s) / SWS (hours per week per semester)
- block work placement (BPr) /
- Department
- Faculty of Technology
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