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502253 Biochemische Analysemethoden - Fehlfaltung und Funktionsverlust von Proteinen (V) (WiSe 2024/2025)
Short comment
- Molekulare Medizin
Contents, comment
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Diese Veranstaltung ist Teil des Clusters "Profilierung: Molekulare Medizin (MOM)", den Link zum Lernraum finden Sie hier: https://moodle.uni-bielefeld.de/course/view.php?id=1837
Studierende 0
Die Studierenden kennen die Bedeutung von Fehlfaltungen als Ursache von Erkrankungen wie der zystischen Fibrose. Sie haben eine Vorstellung von der Faltung von funktionalen Proteinen anhand des Faltungstrichters. Sie kennen Beugungsmethoden zur Strukturbestimmung von Proteinen und können das Programm AlphaFold2 zur Proteinstrukturvorhersage anwenden.
Am Beispiel der zystischen Fibrose wird die Bedeutung von Proteinfehlfaltungen als Ursache von Erkrankungen behandelt. Der Mechanismus der Faltung und die Struktur von funktionalen Proteinen wird besprochen. Es werden Beugungsmethoden wie Cryoelektronenmikroskopie zur Bestimmung von Proteinstrukturen vorgestellt. Moderne Methoden zur Vorhersage von Strukturen wie AlphaFold2 werden an Beispielen von den Studierenden selbst angewendet.
Bibliography
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Als Grundlage für die Vorlesung wird die Publikation Fiedorczuk and Chen, 2022, Cell 185, 158-168, https://doi.org/10.1016/j.cell.2021.12.009 verwendet.
Teaching staff
Managed course
Participation in this course is managed by the Medical Faculty OWL, you cannot add it to your timetable yourself. If necessary, please contact the examination office at this address: pruefungsamt.medizin@uni-bielefeld.de
Dates ( Calendar view )
| Frequency | Weekday | Time | Format / Place | Period | |
|---|---|---|---|---|---|
| one-time | Fr | 09:00-11:30 | R2-A4-314 | 18.10.2024 |
Subject assignments
| Module | Course | Requirements | |
|---|---|---|---|
| 5-I-IP-MOM2 Biochemische Analysemethoden in der molekularen Medizin | Biochemische Analysemethoden | Student information |
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- Last update basic details/teaching staff:
- Friday, September 20, 2024
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- lecture (V) /
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- Medical School OWL
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