392145 Bioinformatische Fragestellungen in der aktuellen Proteomforschung (S) (WiSe 2003/2004)
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Massenspektrometrie ist heutzutage eine der meistverwendeten Analysemethoden in der Proteomik. Ein Massenspektrometer ermittelt in Sekundenbruchteilen die molekularen Massen der in einer Probe enthaltenen Peptide, und dies mit sehr großer Genauigkeit: Moderne Massenspektrometer können Massen bis auf 1/10 einer Protonenmasse genau bestimmen.
Hauptanwendung der Massenspektrometrie in der Proteomik ist die Identifikation von Proteinen mittels Datenbanksuche oder de-novo Sequenzierung. In den letzten 10 Jahren wurden eine Vielzahl von biochemischen und massenspektrometrischen Protokollen entwickelt, um solche Analysen zu ermöglichen. Die zur Analyse von Massenspektren benötigten informatischen Werkzeuge wollen wir in diesem Seminar gemeinsam erarbeiten.
Requirements for participation, required level
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Algorithmen & Datenstrukturen
Bibliography
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Pavel Pevzner, Computational Molecular Biology: An Algorithmic Approach, MIT Press, Cambridge, 2000. Das Kapitel über Massenspektrometrie erklärt einige der Probleme.
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| Frequency | Weekday | Time | Format / Place | Period |
|---|
Subject assignments
| Degree programme/academic programme | Validity | Variant | Subdivision | Status | Semester | LP | |
|---|---|---|---|---|---|---|---|
| Graduate School in Bioinformatics and Genome Research / Promotion | |||||||
| Naturwissenschaftliche Informatik / Diplom | (Enrollment until SoSe 2004) | Biologie; BioI | HS |
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