501358 Akute Leukämien (V) (WiSe 2022/2023)

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Allgemeine Pathologie

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Diese Veranstaltung ist Teil des Clusters "onkologische Erkrankungen des Blutes", den Link zum Lernraum finden Sie hier: https://lernraumplus.uni-bielefeld.de/course/view.php?id=14002

Studierende 1-60


Die Studierenden können pathologische Veränderungen der Blutzellen im Mikroskop erkennen und ihre Charakteristika erklären.

Die Studierenden können pathologische Veränderungen der Blutzusammensetzung und deren Entstehung erklären.

Die Studierenden können typische klinische Präsentationen akuter myeloischer und lymphatischer Leukämien erläutern.

Die Studierenden kennen die Techniken der mikroskopischen Untersuchung von Blut und Knochenmark, Immunphänotypisierung und molekularen Techniken (Zytogenetik, FISH, Sequenzierungen)


Akute Leukämien

Definition: Klonale (neoplastische) Expansion unreifer Blasten auf >20% (30%*) im Knochenmark oder im peripheren Blut

FAB-Klassifikation*: Morphologie, Histochemie

?       Akute myeloische Leukämien: AML M0-M7

?       Akute lymphatische Leukämien: L1, L2, L3

?       Akute undifferenzierte Leukämien

Epidemilologie

Klinische Leitsymptome

Akute Myeloische Leukämien:

Diagnostik:

?       Mikroskopische Untersuchung des Blutes: Differentialblutbild, Blastenausschwemmung

?       Knochenmark: Linksverschiebung, Hiatus leucaemicus

?       Prinzipien der Immunphänotypisierung

?       Molekulare Diagnostik:

o  Zytogenetik

o  FISH

o  Sequenzierungstechniken

WHO-Klassifikation: Berücksichtigung molekularer Befunde

Risikostratifikation anhand Molekularer Befunde

Grundzüge der Therapie: Onkopedia!

Akute Lymphatische Leukämien

Diagnostik:

?       Mikroskopische Untersuchung des Blutes: Differentialblutbild, Blastenausschwemmung

?       Knochenmarksunterscuhung: Immunhistologie

?       Subtypisierung: Immunphänotypisierung. MRD-Diagnostik

WHO-Klassifikation

Grundzüge der Therapie: Onkopedia!

Bibliography

Höfler, Kreipe, Moch: Pathologie - Das Lehrbuch ; Fuchs, Staib, Brümmendorf: Manual Hämatologie

Teaching staff

Managed course

Participation in this course is managed by the Medical Faculty OWL, you cannot add it to your timetable yourself. If necessary, please contact the examination office at this address: pruefungsamt.medizin@uni-bielefeld.de

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Module Course Requirements  
5-I-BI-T Blut und Immunsystem I Blut- und Immunsystem I (Vorlesung) Student information

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Registered number: 60
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WS2022_501358@ekvv.uni-bielefeld.de
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Last update basic details/teaching staff:
Wednesday, October 12, 2022 
Last update times:
Thursday, October 6, 2022 
Last update rooms:
Thursday, October 6, 2022 
Type(s) / SWS (hours per week per semester)
lecture (V) /
Department
University Medical Center OWL / Klinikum Lippe
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