501413 Für die Chancengleichheit wird das zweite X-Chromosom sowieso inaktiviert (V) (WiSe 2022/2023)

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Wissenschaftliches Denken und Handeln (Theorie)

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Diese Veranstaltung ist Teil des Clusters "Wissenschaftliches Denken und Handeln", den Link zum Lernraum finden Sie hier: https://lernraumplus.uni-bielefeld.de/course/view.php?id=13999

Studierende 1-60

  • Die Studierenden können den Mechanismus der Genexpression erläutern.
  • Die Studierenden kennen die Prozesse die (ungleicher) X-Inaktivierung zugrunde liegen und können deren potentiellen Einfluss auf Gesundheit und Krankheit anhand einzelner Beispiele nennen.
  • Die Studierenden können die Rolle von Polymorphismen als Screeningtool beschreiben.


Die Vorlesung ist ein Blended Learning Format in dem die Studierenden, das u.g. Paper anhand von Leitfragen (im LernraumPlus hinterlegt) im Voraus lesen werden. Im interaktiven Teil, werden wir die Fragen besprechen und auf einzelne Methoden der Grundlagenforschung eingehen, bei denen Geschlecht (Sex) ein wichtiges Analysekriterium sein kann.

Ausgangsartikel:
Carrel L & Willard HF, X-inactivation profile reveals extensive variability in X-linked gene expression in females, Nature, 2005 https://www.nature.com/articles/nature03479

Bibliography

  • Guethlein, Nora; Grahlow, Melina; Lewis, Carolin A.; Bork, Stephan; Habel, Ute; Derntl, Birgit (2021): Healthcare for Trans*gender People in Clocchiatti et al., Nat Rev Cancer 2016; 16, pages 330–339. https://www.nature.com/articles/nrc.2016.30
  • Rubtsova K. et al. J Clin Invest. 2015;125(6):2187-2193. https://doi.org/10.1172/JCI78082
  • Oertelt-Prigione S, Autoimmun Rev. 2012 May;11(6-7):A479-85. 10.1016/j.autrev.2011.11.022

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Participation in this course is managed by the Medical Faculty OWL, you cannot add it to your timetable yourself. If necessary, please contact the examination office at this address: pruefungsamt.medizin@uni-bielefeld.de

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5-I-WDH-2 Wissenschaftliches Denken und Handeln I - 2 Klinische Forschung Student information

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Last update basic details/teaching staff:
Wednesday, October 12, 2022 
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Thursday, October 6, 2022 
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Thursday, October 6, 2022 
Type(s) / SWS (hours per week per semester)
lecture (V) /
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Medical School OWL
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