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Herr Dr. Kyle Lauersen

1. Centrum für Biotechnologie - CeBiTec / Arbeitsgruppe O. Kruse

+49 521 106-12289  
+49 521 106-12290  
UHG G2-152 Lage-/Raumplan

2. Fakultät für Biologie / Algenbiotechnologie und Bioenergie

+49 521 106-12289  
UHG G2-152 Lage-/Raumplan

Curriculum Vitae

Nationality: Canadian
German: Permanent Residency

Current Position
Bielefeld University, Faculty of Biology, Algae Biotechnology and Bioenergy Group - Postdoctoral Fellow January 2015-current.
EU Horizon 2020 grant agreement No 640720: PHOTOFUEL
Algae Biotechnology and Bioenergy group, Prof. Dr. Olaf Kruse
Role: research manager and innovation leader, supervision of PhD students

Bielefeld University – D.Sc. (Ph.D.), Dr. rer. nat. Biology 2011-2014
Thesis: Heterologous expression of an ice binding protein from the microalgae Chlamydomonas reinhardtii with an optimized nuclear gene expression system
Thesis: 1.0, Defense: 1.0, Magna cum Laude
Scholar in the Cluster of Industrial Biotechnology - Graduate Cluster (CLIB-GC).

Queen’s University, Canada – Master of Science 2009-2011
Thesis: Lolium perenne antifreeze protein, part of a freeze-tolerance strategy

Queen’s University – Bachelor of Education 2008-2009
Specialty: Intermediate-Senior division
Among many placements, taught one three-week session at the American School Foundation of Monterrey, Mexico.

Queen’s University – Bachelor of Science (Honours) 2004-2008
Biology Major
Honours Thesis: Using an antisense strategy to confirm the identity of a candidate gene in the shrivelled leaf activation tagged mutant poplar and identifying the role of epigenetic modification in the regulation of phenotype in activation tagged Populus (received highest thesis mark of graduating year: 92%).

Scholarships and Awards
• Nominated for the 2019 DFG Heinz Maier-Leibnitz Prize by Bielefeld University, 2018.
• Doctoral Completion Scholarship, Bielefeld Young Researcher’s Fund, Bielefeld, Germany, 2014.
• Cluster of Industrial Biotechnology Graduate School (CLIB-GC) Doctoral Scholarship, Bielefeld, Germany, 2011-2014.
• Jennings Scholarship in Life Sciences Laureate, The Professional Institute of the Public Service of Canada, 2004
• Honour Roll Award, Kingston Collegiate and Vocational Institute, Ontario, Canada, 2003.

• Perozeni, F., Cazzaniga, S., Baier, T., Zanoni, F., Zoccatelli, G., Lauersen, K.J. Wobbe, L., Ballottari, M., 2019. bioRxiv 535989. doi.org/10.1101/535989.

Lauersen, K.J. 2019. Eukaryotic microalgae as hosts for light-driven heterologous isoprenoid production. Planta 249(1) 155-180. Review article

• Baier, T., Kros, D., Feiner, R.C., Lauersen, K.J., Müller, K.M., Kruse, O., 2018. Engineered Fusion Proteins for Efficient Protein Secretion and Purification of a Human Growth Factor from the Green Microalga Chlamydomonas reinhardtii. ACS Synthetic Biology 7(11), 2547–2557.

• Crozet, P., et al. 2018. Birth of a Photosynthetic Chassis: A MoClo Toolkit Enabling Synthetic Biology in the Microalga Chlamydomonas reinhardtii. ACS Synthetic Biology 7(9) 2074-2086.

• Yunus, I.S., Wichmann, J., Wördenweber, R., Lauersen, K.J., Kruse, O., Jones, P. 2018. Synthetic metabolic pathways for photobiological conversion of CO2 into hydrocarbon fuel. Metabolic Engineering 49:201-211.

Lauersen, K. J. (corresponding author), Wichmann, J., Baier, T., Kampranis, S. C., Pateraki, I., Møller, B. L., Kruse, O. 2018. Phototrophic production of heterologous diterpenoids and a hydroxy-functionalized derivative from Chlamydomonas reinhardtii. Metabolic Engineering 49:116-127.

• Harun, I., del Río Chanona, E. A., Wagner, J. L., Lauersen, K. J., Zhang, D., Hellgardt, K. 2018. Photocatalytic production of bisabolene from green microalgae mutant: process analysis and kinetic modelling. Industrial & Engineering Chemistry Research 57(31):10336-10344.

• Baier, T., Wichmann, J., Kruse, O., and Lauersen, K. J. (last author). 2018. Intron-containing algal transgenes mediate efficient recombinant gene expression in the green microalga Chlamydomonas reinhardtii. Nucleic Acids Research 46(13):6909-6919. *senior author

• Wichmann, J., Baier, T., Wentnagel, E., Lauersen, K. J., Kruse, O. 2018. Tailored carbon partitioning for phototrophic production of (E)-α-bisabolene from the green microalga Chlamydomonas reinhardtii. Metabolic Engineering 45:211-222.

Lauersen, K. J., Baier, T., Wichmann, J., Wördenweber, R., Hübner, W., Huser, T., Kruse, O. 2016. Efficient phototrophic production of a high-value sesquiterpenoid from the eukaryotic microalga Chlamydomonas reinhardtii. Metabolic Engineering 38:331-343.

Lauersen, K. J., Willamme, R., Coosemans, N., Joris, M., Kruse, O., Remacle, C. 2016. Peroxisomal microbodies are at the crossroads of acetate assimilation in the green microalga Chlamydomonas reinhardtii. Algal Research 16:266–274.

Lauersen, K. J., Huber, I., Wichmann, J., Kaluza, I., Baier, T., Leiter, A., Gaukel, V., Pütz, B., Kartushin, V., Rattenhol, A., Steinweg, C., von Riesen, L., Posten, C., Gudermann, F., Lütkemeyer, D., Mussgnug, J. H., Kruse, O. 2015. Investigating the dynamics of recombinant protein secretion from a microalgal host. Journal of Biotechnology 215:62-71.

Lauersen, K. J., Kruse, O., Mussgnug, J. H. 2015. Targeted expression of nuclear transgenes in Chlamydomonas reinhardtii with a versatile, modular vector toolkit. Applied Microbiology and Biotechnology 99(8):3491-3503.

Lauersen, K. J., Vanderveer, T. L., Berger, H., Kaluza, I., Mussgnug, J. H., Walker, V. K., Kruse, O. 2013. Ice recrystallization inhibition mediated by a nuclear-expressed and secreted recombinant ice binding protein in the microalga Chlamydomonas reinhardtii. Applied Microbiology and Biotechnology 97 (22):9763-9772.

• Bogen, C., Al-Dilaimi, A., Albersmeier, A., Wichmann, J., Grundmann, M., Rupp, O., Lauersen, K. J., Blifernez-Klassen, O., Kalinowski, J., Goesmann, A. 2013. Reconstruction of the lipid metabolism for the microalga Monoraphidium neglectum from its genome sequence reveals characteristics suitable for biofuel production. BMC Genomics 14(926).

Lauersen, K. J., Berger, H., Mussgnug, J. H., Kruse, O. 2012. Efficient recombinant protein production and secretion from nuclear transgenes in Chlamydomonas reinhardtii. Journal of Biotechnology 167(2):101-110.

Lauersen, K. J., Brown, A., Middleton A. J., Davies, P. L., Walker, V. K. 2011. Expression and characterization of an antifreeze protein from the perennial ryegrass, Lolium perenne. Cryobiology 62 (3):194-201.

Patent Application
Lauersen, K.J., Mussgnug, J.H., and O. Kruse. Expression vector for a secretion and detection system. European Patent Application No. EP12005108.1. Filing date: 10.07.2012.

Specialist Courses
• Whole Cell Biocatalysis and Separation Technologies. Bioengineering process design and heuristics. CLIB-GC Laboratory course. Technical University, Dortmund, Germany. September 25-27, 2012.
• Introduction to Project- and Innovation-management and Patent Law, Wuppertal, Germany. October 7-9, 2013.

Conference Presentations
• Genomics & Systems Biology IX. New York University Abu Dhabi (NYUAD), UAE. Invited Speaker. 04-08.02.2019.
• The 1st European Congress on Photosynthesis Research. Uppsala, Sweden. Speaker. 25-28.06.2018.
• The 4th LASSB Mini-symposium on Systems and Synthetic Biology. NYUAD, UAE. Invited Speaker. 05.02.2018.
• 7th International Bielefeld-CeBiTec Research Conference. Bielefeld, Germany. Selected Speaker. 24-27.09.2017.
• The 7th International Conference on Algal Biomass, Biofuels and Bioproducts. Miami, USA. Speaker. 18-21.06.2017.
• 6th International Bielefeld-CeBiTec Research Conference. Bielefeld, Germany. Selected Speaker. 26-28.09.2016.
• European Roadmap for an Algae-Based Industry. Olhão, Portugal. Speaker. 6-8.04.2016.
• International CeBiTec Research Conference: Advances in industrial biotechnology: Prospects and challenges for the development of algal biotechnology. Bielefeld, Germany. Speaker. 21-24.09.2014.
• 3rd International Conference on Algal Biomass, Biofuels & Bioproducts. Toronto, Canada. Speaker. 16-19.06.2013.
• The 17th International Pushchino School Conference of Young Scientists “Biology – The Science of The XXI Century”. Pushchino, Russia. Speaker. 21-26.04.2013. Winner of best lecture at conference prize.
• Cluster of Industrial Biotechnology (CLIB2021) International Conference. Turning Global Opportunities into Local Values. Düsseldorf, Germany. Student Speaker. 17-18.04.2013.

Invited Lectures and Research Stays Abroad
• Research stay at the Federal University of Rio Grande (FURG), Rio Grande do Sul, Brazil in the group of Prof. Dr. Jose Alberto Viero Costa. 24.10-3.11.2018.
• Le Commissariat à l’énergie atomique et aux énergies alternatives (CEA - French Alternative Energies and Atomic Energy Commission), Caderache, France. Invited by Gilles Peltier, Fred Beisson, & Yonghua Li-Beisson. 13.11.2018.
• Department of Life Sciences, Institute of Botany, University of Liège, Belgium. Invited by Prof. Dr. Claire Remacle. 16.08.2017.
• Institute of General Botany, Johannes Gutenberg-Universität Mainz, Germany. Invited by Dr. Martin Lohr. 30-31.01.2017.
• International research stay at the Institute for Molecular Biosciences (IMB), University of Queensland, Brisbane, Australia in the group of Prof. Dr. Ben Hankamer. 11.10-10.11.2016.
• Department of Life Sciences, Institute of Botany, University of Liège, Belgium. Invited by Prof. Dr. Claire Remacle. 07.03.2016.
• Department of Biology I, Plant Science, Ludwig Maximillians Universität, Munich, Germany. Invited by Prof. Dr. Jörg Nickelsen. 15.01.2016.
• Department of Plant Sciences, University of Cambridge, UK. Invited by Prof. Dr. Alison Smith. 06.11.2014.
• Institute for Plant Biochemistry and Biotechnology, Westfälische Wilhelms-Universität, Münster, Germany. Invited by Prof. Dr. Michael Hippler. 08.05.2014.

Conference Posters
• The 9th Canadian Plant Biotechnology Conference McGill University, Montreal, Canada, 12-15.05.2014. Poster title: A nuclear-expressed and secreted recombinant plant antifreeze protein from Chlamydomonas cultures.
• The 9th Center for Industrial Biotechnology (CeBiTec) Symposium: Molecular Biotechnology. 3-4.04.2014. Poster title: A synthetic Optimized Vector System for Chlamydomonas reinhardtii.
• International CeBiTec Research Conference: Advances in Industrial Biotechnology: Synthetic Pathways and Reaction Cascades, Bielefeld, Germany, 22-25.09.2013. Poster title: Production and secretion of recombinant proteins from eukaryotic microalgae
• The 7th Center for Industrial Biotechnology (CeBiTec) Symposium: Bio-integrated Organic Synthesis in Industry: Biocatalytic Breakthroughs, Industrial Processes, Emerging Fields, 17-19.12.2012. Poster title: Microalgae as bioreactors for high value recombinant protein production.
• 9th European Workshop Biotechnology of Microalgae. Nuthetal, Germany, 4-5.06.2012.
• The 6th Center for Industrial Biotechnology (CeBiTec) Symposium: Genome-Based Microbiology: From -omics Research to Systems and Synthetic Biology. Bielefeld, Germany, 18-20.07.2011.
• European Science Foundation Bielefeld University CeBiTec Conference; Microorganisms for Bio-fuel Production from Sunlight, 18-21.09.2011. Poster title: Systematic optimization of microalgae cultivation for applications in (bio)-industry.

Scientific Work Experience
TIC and TOC Protein Research Assistant 2008
to Prof. Dr. Kenton Ko, Queen’s University
Molecular genetic strategies to screen for yeast mutant lines via polymerase chain reaction.
Development of in vivo plant models for genetic transformation of transmembrane proteins.

Molecular Control of Plant Development Research Assistant 2007-2008
to Prof. Dr. Sharon Regan, Queen’s University
Incorporated aspects of molecular genetic techniques, theory, and experimental design both independently and within a team.
Managed two distinct and complex projects with separate paid staffs.

Queen’s University Phytotron Research Assistant 2006-2007
to Dale Kristensen, Queen’s University
Training in horticultural maintenance, chemical treatment, and experimental design for plant systems’ biology and evolutionary ecology.

Evolutionary Ecology and Mating Patterns Research Assistant 2006
to Prof. Dr. Chris Eckert, Queen’s University
Large-scale complex projects were completed within tight deadlines while working in harsh desert environments.
Intensive field research in the dune ecotone, focusing on community structure and mating patterns of dune species.

Paleolimnology, P.E.A.R.L. Laboratory Research Assistant 2005
to Prof. Dr. Brian Cumming, Queen’s University
This paleolimnology field research included outdoors trekking, boating, sediment core sample collection and treatment, followed by laboratory analysis.

"Die Uni als >>Inkubator<<" 16.01.2019. Westfalen-Blatt (German language newspaper), Author: Sabine Schulze. http://www.westfalen-blatt.de/OWL/Bielefeld/Bielefeld/3620158-Folge-3-Der-Kanadier-Kyle-Lauersen-erforscht-am-Cebitec-einzellige-Algen-Die-Uni-als-Inkubator
"Overcoming limitations of engineering eukaryotic algae." 15.07.2018. Algae Industry Magazine Featured Research Article: http://www.algaeindustrymagazine.com/overcoming-limitations-of-engineering-eukaryotic-algae/
• ImpFest 2016 Imperial College London Festival, Community engagement with genetically modified microbes, Microbial metabolic Engineering group: Dr. Patrik Jones. http://www.youtube.com/watch?v=mKMubTekw9g
“Willkommen in der Zukunft.” 10.2012. H1 Das Magazin der Universität Bielefeld. Author: Daniel Pirker.
“Queen’s grad explores the possibilities of algae.” 08.2011. Queen’s University Alumni Review. Author: Elamin Abdelmamoud.
“Kingston man sees big things in algae, Kyle Lauersen heads to Germany.” 10.03.2011. EMC Newspaper, Kingston, Ontario, Canada. Author: Mark Bergin

Events Organized
• PHOTOFUEL Young Researcher’s Collaboration Meeting at Bielefeld University. 08.07.2016.
• 4th CLIB-GC Student Symposium, Patents in Biotechnology Perspectives from Society and Industry, Bielefeld University Centre for Biotechnology. 11.03.2013. Organizing committee.

Aktuelle Forschungsthemen

My research interests are shared between the fundamental understanding of gene regulation and metabolism in eukaryotic organisms and the use of synthetic biology to enable sustainable biotechnology with microalgae. These organisms are fascinating and can serve as elegant platforms for the development of sustainable biotechnological processes using light and CO2 to generate high-value as well as bulk consumer products. My research leverages the future-focussed technologies collectively known as synthetic biology and metabolic engineering to enable eukaryotic algal genetic engineering aimed at broadening their use as model organisms and green industrial work-horses. I am interested in the use of microalgae as model organisms to probe the nature of eukaryotic genetic regulation, carbon metabolism, and to translate this fundamental understanding into sustainable light-driven green biotechnology concepts.