Stem cells from adult nose tissue used to cure Parkinson’s disease in rats
The team then tested how the ITSCs would behave when transplanted into a group of rats with Parkinson’s disease. Prior to transplantation, the animals showed severe motor and behavioral deficiencies. However, 12 weeks after receiving the ITSCs, the cells had migrated within the animals’ brains and functional ability was not only fully restored, but significant behavioral recovery was witnessed, too. Interestingly regeneration of the endogenous dopaminergic system was observed also. In another positive sign, no tumors were found in any of the animals after the transplantations, something that also has been a concern in stem cell therapy.
“Due to their easy accessibility and the resulting possibility of an autologous transplantation approach, ITSCs represent a promising cell source for regenerative medicine,” said BU’s Barbara Kaltschmidt, Ph.D., who led the study along with Alexander Storch, M.D., of Dresden University of Technology. “The lack of ethical concerns associated with human embryonic stem cells is a plus, too.” Joint first authors are Janine Müller M.Sc. from BU jointly with Christiana Ossig, M.D., from Dresden.
Professorin Dr. Barbara Kaltschmidt, Bielefeld University
Faculty of Biology
Telephone: +49 521 106-5624
Professor Dr. med. Alexander Storch, Dresden University of Technology
Faculty of Medicine Carl Gustav Carus
Clinic and Polyclinic for Neurology
Telephone: +49 351 458 2532