Frau Dr. Lenny Ferrer

During my PhD study, we produced the industrially-relevant odorant indole by debottlenecking regulatory networks and identifying target genes in Corynebacterium glutamicum. Additionally, heterologous pathway introduction and product sequestering were performed. We also constructed a serine-activated biosensor to allow an on-demand conversion of serine and indole derivatives to their corresponding tryptophan derivatives.

References
1. Ferrer, L., Elsaraf M., Mindt, M., Wendisch, V.F. (2022). L-Serine biosensor-controlled fermentative production of L-tryptophan derivatives by Corynebacterium glutamicum. Biology.11, 744.

2. Ferrer, L., Mindt, M., Suarez-Diez, M., Jilg, T., Zagorščak, M., Lee, J.H., Gruden, K., Wendisch, V.F., Cankar, K. (2022). Fermentative indole production via bacterial tryptophan synthase alpha subunit and plant indole-3-glycerol phosphate lyase enzymes. Journal of Agricultural and Food Chemistry.70(18), 5634-5645.

3. Kim, H. -S., Choi, J. -A., Kim, B. Y., Ferrer, L., Choi, J. -M., Wendisch, V. F., & Lee, J. -H. (2022). Engineered Corynebacterium glutamicum as platform for the production of aromatic aldehydes. Frontiers in Bioengineering and Biotechnology.10, 880277.

4. Mindt, M., Kashkooli A.B., Suarez-Diez, M., Ferrer, L., Jilg, T., Bosch, D., Martins dos Santos, V., Wendisch, V.F., Cankar, K. (2022). Production of indole by microbial cell factories for flavor and fragrance applications. Microbial Cell Factories.21(1), 45.

5. Walter, T., Al Medani, N., Burgardt, A., Cankar, K., Ferrer, L., Kerbs, A., ... & Wendisch, V. F. (2020). Fermentative N-methylanthranilate production by engineered Corynebacterium glutamicum. Microorganisms.8(6), 866.

6. Kim, B. Y., Jung, H. B., Lee, J. Y., Ferrer, L., Purwanto, H. S., & Lee, J. H. (2020). Production of 4-hydroxybenzyl alcohol using metabolically engineered Corynebacterium glutamicum. Microbiology and Biotechnology Letters.48(4), 506-514.

7. Purwanto, H. S., Kang, M. S., Ferrer, L., Han, S. S., Lee, J. Y., Kim, H. S., & Lee, J. H. (2018). Rational engineering of the shikimate and related pathways in Corynebacterium glutamicum for 4-hydroxybenzoate production. Journal of biotechnology.282, 92-100.