An international team including Dr Joseph Hoffman from Bielefeld University has shown that advanced DNA sequencing technologies can be used to accurately measure the levels of inbreeding in wild animal populations. The research led by Dr Joseph Hoffman of the Department of Animal Behaviour, Bielefeld University, Germany, and senior author Dr Kanchon Dasmahapatra of the Department of Biology at York, may help efforts to conserve rare species.

Harbour seals. Photo: Oliver Krüger

But the new research, published in PNAS, has used high throughput sequencing, generating more than 10,000 genetic markers, to assess inbreeding in a captive mouse population as well as in wild harbour seals.

Using a zoo population of mice with a known family tree, the researchers first checked the validity of their method for measuring inbreeding. They then carried out autopsies and took DNA samples from harbour seals stranded on Dutch beaches. The study revealed that inbred individuals were more likely to suffer from lung parasite infection.

Dr Hoffman said: “We have shown that in some species inbreeding in the wild may be a bigger problem than previously thought.”

Dr Dasmahapatra explained: “This technique can be used to establish if there is an inbreeding problem in wild populations so that possible remedial action can be taken.”

The study included scientists from University College London, the British Antarctic Survey, Erasmus University and Utrecht University in The Netherlands, CNRS Montpellier, France, and Chicago Zoological Society, USA.

Original publication:
Joseph I. Hoffman, Fraser Simpson, Patrice David, Jolianne M. Rijks, Thijs Kuiken, Michael A. S. Thorne, Robert C. Lacy, Kanchon K. Dasmahapatra: High-throughput sequencing reveals inbreeding depression in a natural population, Proceedings of the National Academy of Sciences, http://dx.doi.org/10.1073/pnas.1318945111, published on 24 February 2014.